Exploring the biological and chemical complexity of the ligases.
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ABSTRACT:
SUBMITTER: Holliday GL
PROVIDER: S-EPMC4018984 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Exploring the biological and chemical complexity of the ligases.
Holliday Gemma L GL Rahman Syed Asad SA Furnham Nicholas N Thornton Janet M JM
Journal of molecular biology 20140321 10
Using a novel method to map and cluster chemical reactions, we have re-examined the chemistry of the ligases [Enzyme Commission (EC) Class 6] and their associated protein families in detail. The type of bond formed by the ligase can be automatically extracted from the equation of the reaction, replicating the EC subclass division. However, this subclass division hides considerable complexities, especially for the C-N forming ligases, which fall into at least three distinct types. The lower level ...[more]
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