Use of glomerular filtration rate estimating equations for drug dosing in HIV-positive patients.

ABSTRACT:

Background

Current HIV treatment guidelines recommend using the Cockcroft-Gault equation for drug dosing adjustments. The use of newer glomerular filtration rate (GFR) estimating equations for drug dosing and the appropriateness of physician antiretroviral dosing based on estimated kidney function have not been studied in an HIV-positive population.

Methods

We evaluated concordance between measured and estimated GFR for the assignment of kidney function categories designated by the US Food and Drug Administration (FDA) Guidance for industry for pharmacokinetic studies, and appropriateness of physician antiretroviral drug dosing for level of kidney function in 200 HIV-positive patients on stable antiretroviral therapy. Estimated kidney function was determined using the Chroni

SUBMITTER: Okparavero AA 

PROVIDER: S-EPMC4018994 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature