Ontology highlight
ABSTRACT:
SUBMITTER: Coppari R
PROVIDER: S-EPMC4019022 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Coppari Roberto R Bjørbæk Christian C
Nature reviews. Drug discovery 20120901 9
Since the discovery of leptin in 1994, we now have a better understanding of the cellular and molecular mechanisms underlying its biological effects. In addition to its established anti-obesity effects, leptin exerts antidiabetic actions that are independent of its regulation of body weight and food intake. In particular, leptin can correct diabetes in animal models of type 1 and type 2 diabetes. In addition, long-term leptin replacement therapy improves glycaemic control, insulin sensitivity an ...[more]