Targeting the Fc receptor in autoimmune disease.

ABSTRACT:

Introduction

The Fc receptors (FcRs) and their interactions with immunoglobulin and innate immune opsonins, such as C-reactive protein, are key players in humoral and cellular immune responses. As the effector mechanism for some therapeutic monoclonal antibodies, and often a contributor to the pathogenesis and progression of autoimmunity, FcRs are promising targets for treating autoimmune diseases.

Areas covered

This review discusses the nature of different FcRs and the various mechanisms of their involvement in initiating and modulating immunocyte functions and their biological consequences. It describes a range of current strategies in targeting FcRs and manipulating their interaction with specific ligands, while presenting the pros and cons of these approaches. This revie

SUBMITTER: Li X 

PROVIDER: S-EPMC4019044 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature