Ontology highlight
ABSTRACT:
SUBMITTER: Tapia-Alveal C
PROVIDER: S-EPMC4019066 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Tapia-Alveal Claudia C Lin Su-Jiun SJ Yeoh Aaron A Jabado Omar J OJ O'Connell Matthew J MJ
Molecular and cellular biology 20140331 11
Structural maintenance of chromosomes (SMC) complexes and DNA topoisomerases are major determinants of chromosome structure and dynamics. The cohesin complex embraces sister chromatids throughout interphase, but during mitosis most cohesin is stripped from chromosome arms by early prophase, while the remaining cohesin at kinetochores is cleaved at anaphase. This two-step removal of cohesin is required for sister chromatids to separate. The cohesin-related Smc5/6 complex has been studied mostly a ...[more]