Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi T
PROVIDER: S-EPMC4019142 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Kobayashi Tomoko T Koizumi Yoshiki Y Takeuchi Junko S JS Misawa Naoko N Kimura Yuichi Y Morita Satoru S Aihara Kazuyuki K Koyanagi Yoshio Y Iwami Shingo S Sato Kei K
Journal of virology 20140312 10
APOBEC3F and APOBEC3G cytidine deaminases potently inhibit human immunodeficiency virus type 1 (HIV-1) replication by enzymatically inserting G-to-A mutations in viral DNA and/or impairing viral reverse transcription independently of their deaminase activity. Through experimental and mathematical investigation, here we quantitatively demonstrate that 99.3% of the antiviral effect of APOBEC3G is dependent on its deaminase activity, whereas 30.2% of the antiviral effect of APOBEC3F is attributed t ...[more]