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Gold Catalysed Redox Synthesis of Imidazo[1,2-a]pyridine using Pyridine N-Oxide and Alkynes.


ABSTRACT: A mild, catalytic, atom economical synthesis of imidazo[1,2-a]pyridines has been developed: catalytic PicAuCl2 in the presence of an acid produces a range imidazo[1,2-a]pyridines in good yield. This strategy is mild and forseen to be of particular use for the installation of stereogenic centers adjacent to the imidazo[1,2-a]pyridine ring without loss of enantiomeric excess.

SUBMITTER: Talbot EP 

PROVIDER: S-EPMC4019451 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Gold Catalysed Redox Synthesis of Imidazo[1,2-<i>a</i>]pyridine using Pyridine <i>N</i>-Oxide and Alkynes.

Talbot Eric P A EP   Richardson Melodie M   McKenna Jeffrey M JM   Toste F Dean FD  

Advanced synthesis & catalysis 20140301 4


A mild, catalytic, atom economical synthesis of imidazo[1,2-<i>a</i>]pyridines has been developed: catalytic PicAuCl<sub>2</sub> in the presence of an acid produces a range imidazo[1,2-<i>a</i>]pyridines in good yield. This strategy is mild and forseen to be of particular use for the installation of stereogenic centers adjacent to the imidazo[1,2-<i>a</i>]pyridine ring without loss of enantiomeric excess. ...[more]

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