Ontology highlight
ABSTRACT:
SUBMITTER: Kaza N
PROVIDER: S-EPMC4019476 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kaza Niroop N Kohli Latika L Graham Christopher D CD Klocke Barbara J BJ Carroll Steven L SL Roth Kevin A KA
PloS one 20140513 5
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive Schwann cell-derived sarcomas and are the leading cause of mortality in patients with neurofibromatosis type 1 (NF1). Current treatment modalities have been largely ineffective, resulting in a high rate of MPNST recurrence and poor five-year patient survival. This necessitates the exploration of alternative chemotherapeutic options for MPNST patients. This study sought to assess the cytotoxic effect of the BH3-mimetic AT101 [(-)-go ...[more]