Ontology highlight
ABSTRACT:
SUBMITTER: Mana-Capelli S
PROVIDER: S-EPMC4019498 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Mana-Capelli Sebastian S Paramasivam Murugan M Dutta Shubham S McCollum Dannel D
Molecular biology of the cell 20140319 10
The Hippo pathway regulates the transcriptional coactivator YAP to control cell proliferation, organ size, and stem cell maintenance. Multiple factors, such as substrate stiffness, cell density, and G protein-coupled receptor signaling, regulate YAP through their effects on the F-actin cytoskeleton, although the mechanism is not known. Here we show that angiomotin proteins (AMOT130, AMOTL1, and AMOTL2) connect F-actin architecture to YAP regulation. First, we show that angiomotins are required t ...[more]