FOXM1 modulates cisplatin sensitivity by regulating EXO1 in ovarian cancer.
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ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC4019642 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
FOXM1 modulates cisplatin sensitivity by regulating EXO1 in ovarian cancer.
Zhou Jinhua J Wang Yunfei Y Wang You Y Yin Xia X He Yifeng Y Chen Lilan L Wang Wenwen W Liu Ting T Di Wen W
PloS one 20140513 5
Cisplatin is commonly used in ovarian cancer chemotherapy, however, chemoresistance to cisplatin remains a great clinical challenge. Oncogenic transcriptional factor FOXM1 has been reported to be overexpressed in ovarian cancer. In this study, we aimed to investigate the potential role of FOXM1 in ovarian cancers with chemoresistance to cisplatin. Our results indicate that FOXM1 is upregulated in chemoresistant ovarian cancer samples, and defends ovarian cancer cells against cytotoxicity of cisp ...[more]
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