Dopaminergic modulation of cAMP drives nonlinear plasticity across the Drosophila mushroom body lobes.

ABSTRACT:

Background

Activity of dopaminergic neurons is necessary and sufficient to evoke learning-related plasticity in neuronal networks that modulate learning. During olfactory classical conditioning, large subsets of dopaminergic neurons are activated, releasing dopamine across broad sets of postsynaptic neurons. It is unclear how such diffuse dopamine release generates the highly localized patterns of plasticity required for memory formation.

Results

Here we have mapped spatial patterns of dopaminergic modulation of intracellular signaling and plasticity in Drosophila mushroom body (MB) neurons, combining presynaptic thermogenetic stimulation of dopaminergic neurons with postsynaptic functional imaging in vivo. Stimulation of dopaminergic neurons generated increases in cyclic AM

SUBMITTER: Boto T 

PROVIDER: S-EPMC4019670 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature