Ontology highlight
ABSTRACT:
SUBMITTER: Davis MR
PROVIDER: S-EPMC4019825 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Molecular genetics and metabolism 20131216 1
The fibrillins and latent transforming growth factor binding proteins (LTBPs) form a superfamily of extracellular matrix (ECM) proteins characterized by the presence of a unique domain, the 8-cysteine transforming growth factor beta (TGFβ) binding domain. These proteins are involved in the structure of the extracellular matrix and controlling the bioavailability of TGFβ family members. Genes encoding these proteins show differential expression in mesenchymal cell types which synthesize the extra ...[more]