Ontology highlight
ABSTRACT:
SUBMITTER: Danilchanka O
PROVIDER: S-EPMC4020113 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Danilchanka Olga O Sun Jim J Pavlenok Mikhail M Maueröder Christian C Speer Alexander A Siroy Axel A Marrero Joeli J Trujillo Carolina C Mayhew David L DL Doornbos Kathryn S KS Muñoz Luis E LE Herrmann Martin M Ehrt Sabine S Berens Christian C Niederweis Michael M
Proceedings of the National Academy of Sciences of the United States of America 20140421 18
The ability to control the timing and mode of host cell death plays a pivotal role in microbial infections. Many bacteria use toxins to kill host cells and evade immune responses. Such toxins are unknown in Mycobacterium tuberculosis. Virulent M. tuberculosis strains induce necrotic cell death in macrophages by an obscure molecular mechanism. Here we show that the M. tuberculosis protein Rv3903c (channel protein with necrosis-inducing toxin, CpnT) consists of an N-terminal channel domain that is ...[more]