Ontology highlight
ABSTRACT:
SUBMITTER: Taylor PR
PROVIDER: S-EPMC4020181 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Taylor Patricia R PR Leal Sixto M SM Sun Yan Y Pearlman Eric E
Journal of immunology (Baltimore, Md. : 1950) 20140303 7
Fusarium and Aspergillus species of mold are major causes of corneal infections in the United States and worldwide, resulting in severe visual impairment and blindness. As there is evidence for T cell responses to these pathogenic fungi in infected individuals, we examined the role of IL-17A (IL-17) and IFN-γ in murine models of fungal keratitis. We found that C57BL/6 mice given intratracheal or s.c. immunization of conidia prior to corneal infection exhibited enhanced fungal killing and lower c ...[more]