Ontology highlight
ABSTRACT:
SUBMITTER: Yousefzadeh P
PROVIDER: S-EPMC4020458 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Yousefzadeh Pegah P Shapses Sue A SA Wang Xiangbing X
International journal of endocrinology 20140428
There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to exert biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10-15% is bound ...[more]