Ontology highlight
ABSTRACT:
SUBMITTER: Yang YS
PROVIDER: S-EPMC4020744 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20140514 5
A series of novel 2-(1,3-diaryl- 4,5-dihydro-1H-pyrazol-5-yl)phenol derivatives (C1-C24) have been synthesized. The B-Raf inhibitory activity and anti-proliferation activity of these compounds have been tested. Compound C6 displayed the most potent biological activity against B-RafV600E (IC50 = 0.15 µM) and WM266.4 human melanoma cell line (GI50 = 1.75 µM), being comparable with the positive control (Vemurafenib and Erlotinib) and more potent than our previous best compounds. The docking simulat ...[more]