Ontology highlight
ABSTRACT:
SUBMITTER: Shearer AG
PROVIDER: S-EPMC4020792 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Shearer Alexander G AG Altman Tomer T Rhee Christine D CD
PloS one 20140514 5
Despite advances in sequencing technology, there are still significant numbers of well-characterized enzymatic activities for which there are no known associated sequences. These 'orphan enzymes' represent glaring holes in our biological understanding, and it is a top priority to reunite them with their coding sequences. Here we report a methodology for resolving orphan enzymes through a combination of database search and literature review. Using this method we were able to reconnect over 270 or ...[more]