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Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.


ABSTRACT:

Background

Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes.

Methods

Three hundred and ninety-eight consecutive diabetic patients from a single outpatient clinic received a standardized questionnaire on osteoporosis risk factors, and were evaluated for diabetes-related complications, HbA1c levels, and lumbar spine (LS) and femoral neck (FN) BMD. Of these, 139 (71 men, 68 women) type 1 and 243 (115 men, 128 women) type 2 diabetes patients were included in the study. BMD (T-scores and values adjusted for age, BMI and duration of disease) was compared between patient groups and between patients with type 2 diabetes and population-based controls (255 men, 249 women).

Results

For both genders, adjusted BMD was not different between the type 1 and type 2 diabetes groups but was higher in the type 2 group compared with controls (p?ConclusionsDiabetes-specific parameters did not predict BMD. Fracture occurrence was similar in both diabetes groups and related to lower BMD, but seems unrelated to the threshold T-score, <-2.5 SD. These results suggest that osteoporosis, and related fractures, is a clinically significant and commonly underestimated problem in diabetes patients.

SUBMITTER: Leidig-Bruckner G 

PROVIDER: S-EPMC4021186 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.

Leidig-Bruckner Gudrun G   Grobholz Sonja S   Bruckner Thomas T   Scheidt-Nave Christa C   Nawroth Peter P   Schneider Jochen G JG  

BMC endocrine disorders 20140411


<h4>Background</h4>Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes.<h4>Methods</h4>Three hundred and ninety-eight consecutive diabetic patients from a single outpatient clinic received a standardized questionnaire on osteoporosis risk factors, and were evaluated for diabetes-related complications, HbA1c levels, and lumba  ...[more]

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