Dataset Information

Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial.

ABSTRACT: Little is known about the effect of preventive diets on colonic nutrient concentrations. This study randomized 120 persons at increased risk of colon cancer to a Mediterranean versus a Healthy Eating diet for six months. The former targeted increases in whole grains, fruits, vegetables, monounsaturated, and n3 fats. The Healthy Eating diet was based on Healthy People 2010 recommendations. At baseline, dietary fat and carotenoid intakes were poorly associated (Spearman ? < 0.4) with serum and colon concentrations. Strong associations were observed between serum and colon measurements of ?-cryptoxanthin (? = 0.58; P < 0.001), ?-carotene (? = 0.48; P < 0.001), and ?-carotene (? = 0.45; P < 0.001). After six months, the Healthy Eating intervention increased serum lutein, ?-, and ?-carotene significantly (P < 0.05). In the Mediterranean arm, the significant increases were in serum lutein, ?-cryptoxanthin, ?-carotene, monounsaturated, and n3 fats. A significant group-by-time interaction (P = 0.03) was obtained for monounsaturated fats. Colonic increases in carotenoids and n3 fats were significant only in Healthy Eating arm, whereas the group-by-time interaction was significant for ?-carotene (P = 0.02) and ?-carotene (P = 0.03). Changes in colon concentrations were not significantly associated with reported dietary changes. Changes in colon and serum concentrations were strongly associated for ?-cryptoxanthin (? = 0.56; P < 0.001) and ?-carotene (? = 0.40; P < 0.001). The associations between colonic and serum concentrations suggest the potential use of using serum concentration as a target in dietary interventions aimed at reducing colon cancer risk.

SUBMITTER: Sen A

PROVIDER: S-EPMC4021591 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial.

Sen Ananda A Ren Jianwei J Ruffin Mack T MT Turgeon Danielle K DK Brenner Dean E DE Sidahmed Elkhansa E Rapai Mary E ME Cornellier Maria L ML Djuric Zora Z

Cancer prevention research (Philadelphia, Pa.) 20130416 6

Little is known about the effect of preventive diets on colonic nutrient concentrations. This study randomized 120 persons at increased risk of colon cancer to a Mediterranean versus a Healthy Eating diet for six months. The former targeted increases in whole grains, fruits, vegetables, monounsaturated, and n3 fats. The Healthy Eating diet was based on Healthy People 2010 recommendations. At baseline, dietary fat and carotenoid intakes were poorly associated (Spearman ρ < 0.4) with serum and col ...[more]

PMID: 23592741

Similar Datasets

Project description:BackgroundPreviously, a "purchase" pattern (rich in vegetable oil, manufactured foods, red meat and poultry, fruits, and vegetables) was identified among adults in urban Ghana and was inversely associated with T2D, while a "traditional" pattern (rich in fish, palm oil, plantain, green-leafy vegetables, beans, garden egg, fermented maize products,) increased the odds of T2D. To investigate, if specific fatty acids (FAs), partly reflecting the intakes of certain food groups and cooking methods, might explain the observed diet-disease relationships, serum phospholipid fatty acid profiles were characterized and their relationships with blood lipids that are common risk factors for T2D were analyzed.MethodsThe relative proportions of 28 FAs (%) in 653 Ghanaians without T2D were measured by gas chromatography. In a cross-sectional analysis, the associations of FAs with dietary patterns and with serum lipids that are likely involved in T2D development were investigated. The FAs distributions across dietary pattern scores were examined. Standardized beta coefficients (β) were calculated for the associations of dietary pattern scores (per 1 standard deviation (SD) increase) with FAs. Across the tertiles of selected diet-related FAs, adjusted means of serum triglycerides, cholesterol, HDL-cholesterol and LDL-cholesterol were calculated.ResultsIn this mainly female (76%), middle-aged (mean age: 46.4, SD: 15.3 years) and predominately overweight study population (mean body mass index: 25.8, SD: 5.4 kg/m2), saturated FAs (SFAs) contributed 52% to total serum FAs, n-6 polyunsaturated FAs (PUFAs) 27%, monounsaturated FAs 12%, n-3 PUFAs 9% and trans FAs (TFAs) <1%. The "purchase" pattern was related to lower proportions of n-3 PUFAs (β per 1 score SD: -0.25, p < 0.0001), but higher proportions of linoleic acid (LA) (β per 1 score SD: 0.24, p < 0.0001). The "traditional" pattern was characterized by lower proportions of arachidic acid (β per 1 score SD: -0.10, p = 0.001). LA was inversely associated with triglycerides, but positively with HDL-cholesterol and LDL-cholesterol.ConclusionsIn this Ghanaian population, serum FA profiles reflected the intake of key components of dietary patterns, such as fish and vegetable oil. FAs from manufactured foods (SFAs) and deep-fried meals (TFAs) did not contribute to the observed associations between dietary patterns and T2D. Still, LA might partly explain the health-beneficial effect of the "purchase" pattern.

Dataset Information

Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial.

Publications

Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets