Ontology highlight
ABSTRACT:
SUBMITTER: Linford AS
PROVIDER: S-EPMC4022148 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Linford Alicia S AS Jiang Nona M NM Edwards Thomas E TE Sherman Nicholas E NE Van Voorhis Wesley C WC Stewart Lance J LJ Myler Peter J PJ Staker Bart L BL Petri William A WA
Molecular and biochemical parasitology 20140101 1
Entamoeba histolytica is a eukaryotic intestinal parasite of humans, and is endemic in developing countries. We have characterized the E. histolytica putative low molecular weight protein tyrosine phosphatase (LMW-PTP). The structure for this amebic tyrosine phosphatase was solved, showing the ligand-induced conformational changes necessary for binding of substrate. In amebae, it was expressed at low but detectable levels as detected by immunoprecipitation followed by immunoblotting. A mutant LM ...[more]