High oleic/stearic fatty-acid desaturation index in cord plasma from infants of mothers with gestational diabetes.

ABSTRACT:

Objective

Enhanced fatty-acid desaturation by stearoyl-CoA desaturase enzyme-1 (SCD1) is associated with obesity. This study determined desaturation in the cord plasma of newborns of mothers with and without gestational diabetes (GDM).

Study design

Newborns of mothers with GDM (n=21) and without (control, n=22) were recruited. Cord plasma fatty-acid desaturation indices (palmitoleic/palmitic, oleic/stearic ratios) were compared, and correlated with anthropometrics and biochemical measures. A subset of very low-density lipoprotein (VLDL) desaturation indices were determined to approximate the liver SCD1 activity.

Result

The total oleic/stearic index was higher in GDM, despite adjustment for cord glucose concentrations. Among GDM and controls, the oleic/stearic index co

SUBMITTER: Yee JK 

PROVIDER: S-EPMC4022182 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature