Ontology highlight
ABSTRACT:
SUBMITTER: Kaplan JS
PROVIDER: S-EPMC4022289 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Kaplan Joshua S JS Kaplan Joshua S JS Mohr Claudia C Rossi David J DJ
Nature neuroscience 20131027 12
The molecular mechanisms that mediate genetic variability in response to alcohol are unclear. We found that alcohol had opposite actions (enhancement or suppression) on GABA(A) receptor (GABA(A)R) inhibition in granule cells from the cerebellum of behaviorally sensitive, low alcohol-consuming Sprague-Dawley rats and DBA/2 mice and behaviorally insensitive, high alcohol-consuming C57BL/6 mice, respectively. The effect of alcohol on granule cell GABA(A)R inhibition was determined by a balance betw ...[more]