Slow noise in the period of a biological oscillator underlies gradual trends and abrupt transitions in phasic relationships in hybrid neural networks.

ABSTRACT: In order to study the ability of coupled neural oscillators to synchronize in the presence of intrinsic as opposed to synaptic noise, we constructed hybrid circuits consisting of one biological and one computational model neuron with reciprocal synaptic inhibition using the dynamic clamp. Uncoupled, both neurons fired periodic trains of action potentials. Most coupled circuits exhibited qualitative changes between one-to-one phase-locking with fairly constant phasic relationships and phase slipping with a constant progression in the phasic relationships across cycles. The phase resetting curve (PRC) and intrinsic periods were measured for both neurons, and used to construct a map of the firing intervals for both the coupled and externally forced (PRC measurement) conditions. For the couple

SUBMITTER: Thounaojam US 

PROVIDER: S-EPMC4022488 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature