Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations.
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ABSTRACT:
SUBMITTER: Vilasi S
PROVIDER: S-EPMC4022648 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations.
Vilasi Silvia S Carrotta Rita R Mangione Maria Rosalia MR Campanella Claudia C Librizzi Fabio F Randazzo Loredana L Martorana Vincenzo V Marino Gammazza Antonella A Ortore Maria Grazia MG Vilasi Annalisa A Pocsfalvi Gabriella G Burgio Giosalba G Corona Davide D Palumbo Piccionello Antonio A Zummo Giovanni G Bulone Donatella D Conway de Macario Everly E Macario Alberto J L AJ San Biagio Pier Luigi PL Cappello Francesco F
PloS one 20140515 5
It has been established that Hsp60 can accumulate in the cytosol in various pathological conditions, including cancer and chronic inflammatory diseases. Part or all of the cytosolic Hsp60 could be naïve, namely, bear the mitochondrial import signal (MIS), but neither the structure nor the in solution oligomeric organization of this cytosolic molecule has still been elucidated. Here we present a detailed study of the structure and self-organization of naïve cytosolic Hsp60 in solution. Results we ...[more]
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