Ontology highlight
ABSTRACT:
SUBMITTER: Serrano-Villar S
PROVIDER: S-EPMC4022662 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Serrano-Villar Sergio S Sainz Talia T Lee Sulggi A SA Hunt Peter W PW Sinclair Elizabeth E Shacklett Barbara L BL Ferre April L AL Hayes Timothy L TL Somsouk Ma M Hsue Priscilla Y PY Van Natta Mark L ML Meinert Curtis L CL Lederman Michael M MM Hatano Hiroyu H Jain Vivek V Huang Yong Y Hecht Frederick M FM Martin Jeffrey N JN McCune Joseph M JM Moreno Santiago S Deeks Steven G SG
PLoS pathogens 20140515 5
A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal CD4+ T cell counts. The immunologic and clinical characteristics of this clinical phenotype remain undefined. Using data from four distinct clinical cohorts and three clinical trials, we show that a low CD4/CD8 ratio in HIV-infected adults during oth ...[more]