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Human papillomavirus-associated adenocarcinoma of the base of tongue: potentially actionable genetic changes.

ABSTRACT: While human papillomavirus (HPV)-positive squamous and adenosquamous carcinomas of the oropharynx have been well characterized, HPV-associated pure adenocarcinomas are exceptionally rare. Herein we report the clinicopathologic features of one such HPV-associated adenocarcinoma of the base of tongue (BOT). A 70 year-old male presented with a 2.8 cm base of tongue mass and lymphadenopathy. Immunohistochemically, the adenocarcinoma was p63 negative and p16 positive. HPV positivity was shown by in situ hybridization. Features of salivary type tumor or metastasis from a distant primary were absent. IonTorrent™ semiconductor sequencing analysis for 739 cancer-associated mutations in 46 actionable cancer genes was performed and PIK3CA exon 9 (p.E545K) and MET exon 2 (p.E168D) mutations were identified. No PIK3CA or MET amplification was identified by fluorescence in situ hybridization. A re-review of archival HPV-positive oropharyngeal squamous cell carcinomas (n = 89, 1983-2013) showed no additional cases of adenocarcinoma. The clinical follow-up for the three previously reported cases of HPV-associated adenocarcinoma of the BOT was updated. All previously reported cases were tested and were negative for PIK3CA exon 9 and 20 and MET exon 2 mutations. These findings offer a molecular basis for potential therapeutic use of PIK3CA inhibitors in a subset of patients with HPV-associated adenocarcinoma of BOT.

SUBMITTER: Chang AM

PROVIDER: S-EPMC4022938 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Human papillomavirus-associated adenocarcinoma of the base of tongue: potentially actionable genetic changes.

Chang Ann Margaret V AM Nikiforova Marina N MN Johnson Jonas T JT Bauman Julie E JE Perez-Ordonez Bayardo B Seethala Raja R RR Krane Jeffrey F JF Chiosea Simion I SI

Head and neck pathology 20131121 2

While human papillomavirus (HPV)-positive squamous and adenosquamous carcinomas of the oropharynx have been well characterized, HPV-associated pure adenocarcinomas are exceptionally rare. Herein we report the clinicopathologic features of one such HPV-associated adenocarcinoma of the base of tongue (BOT). A 70 year-old male presented with a 2.8 cm base of tongue mass and lymphadenopathy. Immunohistochemically, the adenocarcinoma was p63 negative and p16 positive. HPV positivity was shown by in s ...[more]

PMID: 24258618

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Project description:BackgroundRecent trends in the incidence of lung cancer have been reported despite the decreasing rate of smoking. Lung cancer is ranked among the top causes of cancer-related deaths. The ratio of adenocarcinoma to squamous cell carcinoma, as well as the ratio of women to men, is still increasing. Human papillomavirus (HPV) has been discovered in lung cancer tissues and blood specimens, particularly in Eastern countries. However, the association between HPV infection and lung adenocarcinoma remains unclear.MethodsThis population-based cohort study was conducted using data from Taiwan's single-payer national health insurance and cancer registry databases. Data on HPV infection, cancer, sex, age, comorbidities, urbanization, and occupation were collected. The cumulative incidence rates were generated using Kaplan-Meier curves and log-rank tests. COX regression analysis was used to estimate the hazard ratios of factors associated with cancer occurrence. We used data from 2007 and 2015. The cases were matched with sex and age in a 1:2 manner with 939,874 HPV+ and 1,879,748 HPV- individuals, respectively.ResultsThe adjusted hazard ratios [95% confidence interval (CI)] for HPV infection in all lung cancers were 1.539 (1.436-1.649), male lung cancer 1.434 (1.312-1.566), female lung cancer 1.742 (1.557-1.948), squamous cell carcinoma (SCC) 1.092 (0.903-1.320), male SCC 1.092 (0.903-1.320), female SCC 0.949 (0.773-1.164), adenocarcinoma 1.714 (1.572-1.870), male adenocarcinoma 1.646 (1.458-1.858), and female adenocarcinoma 1.646 (1.458-1.858). The highest adjusted hazard ratio for lung cancer was chronic obstructive pulmonary disease (COPD) 1.799 (1.613-2.007), followed by male sex 1.567 (1.451-6.863) and HPV infection. The highest adjusted hazard ratio for adenocarcinoma was HPV infection 1.714 (1.572-1.870), followed by COPD 1.300 (1.102-1.533), and for SCC, male sex 5.645 (4.43-3.37), followed by COPD 2.528 (2.002-3.192).ConclusionOur study showed that HPV infection was associated with the occurrence of adenocarcinoma of the lung in both men and women but was not associated with SCC of the lung.

Dataset Information

Human papillomavirus-associated adenocarcinoma of the base of tongue: potentially actionable genetic changes.

Publications

Human papillomavirus-associated adenocarcinoma of the base of tongue: potentially actionable genetic changes.

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