Ontology highlight
ABSTRACT:
SUBMITTER: Rossi M
PROVIDER: S-EPMC4023220 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Rossi Mari M Kilpinen Helena H Muona Mikko M Surakka Ida I Ingle Catherine C Lahtinen Jenni J Hennah William W Ripatti Samuli S Hovatta Iiris I
European journal of human genetics : EJHG 20131030 6
Disrupted-in-schizophrenia-1 (DISC1) gene has been established as a risk factor for various neuropsychiatric phenotypes. Both coding and regulatory variants in DISC1 have been identified and associated with these phenotypes in genetic studies. MicroRNAs (miRNAs) are important regulators of protein coding genes. Since the miRNA-mRNA target recognition mechanism is vulnerable to disruption by DNA polymorphisms, we investigated whether polymorphisms in the DISC1 3'UTR affect binding of miRNAs and l ...[more]