Ontology highlight
ABSTRACT:
SUBMITTER: Quinn RP
PROVIDER: S-EPMC4023292 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Quinn Robert P RP Mahoney Sarah J SJ Wilkinson Barrie M BM Thornton David J DJ Stirling Colin J CJ
Glycobiology 20090619 12
Glucosidase II (GluII) is a glycan-trimming enzyme active on nascent glycoproteins in the endoplasmic reticulum (ER). It trims the middle and innermost glucose residues (Glc2 and Glc1) from N-linked glycans. The monoglucosylated glycan produced by the first GluII trimming reaction is recognized by calnexin/calreticulin and serves as the signal for entry into this folding pathway. GluII is a heterodimer of alpha and beta subunits corresponding to yeast Gls2p and Gtb1p, respectively. While Gls2p c ...[more]