Ontology highlight
ABSTRACT:
SUBMITTER: Yao H
PROVIDER: S-EPMC4023423 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Yao Huilan H Goldman Devorah C DC Nechiporuk Tamilla T Kawane Sunita S McWeeney Shannon K SK Tyner Jeffrey W JW Fan Guang G Kerenyi Marc A MA Orkin Stuart H SH Fleming William H WH Mandel Gail G
Blood 20140320 20
The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation. Definitive erythroid cells from mutant mice arrest at the transition from proerythroblast to basophilic erythroblast. Remarkably, Rcor1 null erythroid progenitors cultured in vitro form myeloid colonies instead of erythroid colonies. The mutant proerythroblasts also aberrantly express genes of the myel ...[more]