Ontology highlight
ABSTRACT:
SUBMITTER: Benezech C
PROVIDER: S-EPMC4023425 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Bénézech Cécile C Nayar Saba S Finney Brenda A BA Withers David R DR Lowe Kate K Desanti Guillaume E GE Marriott Clare L CL Watson Steve P SP Caamaño Jorge H JH Buckley Christopher D CD Barone Francesca F
Blood 20140214 20
The importance of CLEC-2, a natural ligand/receptor for Gp38/Podoplanin, in the formation of the lymphatic vasculature has recently been demonstrated. As the development and maintenance of lymph nodes (LNs) is dependent on the formation of the lymphatic vasculature and the differentiation of Gp38/Podoplanin(+) stromal cells, we investigated the role of CLEC-2 in lymphoneogenesis and LN homeostasis. Using constitutive Clec1b(-/-) mice, we showed that while CLEC-2 was not necessary for initiation ...[more]