Dataset Information

Association between serotonin transport polymorphisms and postdischarge nausea and vomiting in women following breast cancer surgery.

ABSTRACT: To examine the association of the serotonin transport gene and postdischarge nausea and vomiting (PDNV) in women following breast cancer surgery.A cross-sectional study.A comprehensive cancer center in Pittsburgh, PA.80 post-menopausal women treated surgically for early-stage breast cancer.Data were collected using standardized instruments after surgery but before the initiation of chemotherapy. Blood or saliva were used for DNA extraction and analyzed following standardized protocols. Data were analyzed using descriptive statistics and logistic regression.Serotonin transport gene (SLC6A4), nausea, vomiting, pain, and anxiety.Women who inherited the LA/LA genotypes were at greater risk for nausea and vomiting when compared to women who carried any other combination of genotypes. Twenty-one percent of women reported nausea and vomiting an average of one month following surgery and prior to initiation of adjuvant therapy. Those women who experienced PDNV reported significantly higher anxiety and pain scores.Findings of this study suggest that variability in the genotypes of the serotonin transport gene may help to explain the variability in PDNV in women following breast cancer surgery and why 20%-30% of patients do not respond to antiemetic medications.Nurses need to be aware that women who do not experience postoperative nausea and vomiting following surgery for breast cancer continue to be at risk for PDNV long after they have been discharged from the hospital, and this frequently is accompanied by pain and anxiety.

SUBMITTER: Wesmiller SW

PROVIDER: S-EPMC4023462 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Association between serotonin transport polymorphisms and postdischarge nausea and vomiting in women following breast cancer surgery.

Wesmiller Susan W SW Bender Catherine M CM Sereika Susan M SM Ahrendt Gretchen G Bonaventura Marguerite M Bovbjerg Dana H DH Conley Yvette Y

Oncology nursing forum 20140301 2

<h4>Purpose/objectives</h4>To examine the association of the serotonin transport gene and postdischarge nausea and vomiting (PDNV) in women following breast cancer surgery.<h4>Design</h4>A cross-sectional study.<h4>Setting</h4>A comprehensive cancer center in Pittsburgh, PA.<h4>Sample</h4>80 post-menopausal women treated surgically for early-stage breast cancer.<h4>Methods</h4>Data were collected using standardized instruments after surgery but before the initiation of chemotherapy. Blood or sal ...[more]

PMID: 24578078

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Project description:Postoperative nausea and vomiting (PONV) is one of the most common adverse outcomes after strabismus surgery. The primary outcome of this prospective, randomized, double-blind study was to compare the incidences of nausea or vomiting, and patient satisfaction of ondansetron and ramosetron after strabismus surgery under general anesthesia. The secondary outcome was to investigate whether the number of involved extraocular muscles (EOMs) in strabismus surgery was related to PONV.One hundred and five patients (aged 18-60 years) undergoing strabismus surgery were allocated randomly to one of the three groups: placebo, ondansetron, or ramosetron. Patients received 2 ml placebo, 4 mg ondansetron, or 0.3 mg ramosetron at the end of surgery. Each of the three groups was subdivided into two subgroups according to the number of EOMs involved in the surgery: subgroup S, single-muscle correction; subgroup M, multiple-muscle correction. The incidences of nausea or vomiting, and patient satisfaction at 2, 24 and 48 h after surgery were analyzed as primary outcome. With regard to subgroups S and M in the placebo, ondansetron and ramosetron groups, incidences of nausea or vomiting, and patient satisfaction at 2, 24 and 48 h after surgery were analyzed as seconadary outcome.The incidence of nausea was significantly lower in the ramosetron group at 2 h (9.4 %) than in the placebo (45.2 %) and ondansetron (34.7 %) groups (P < 0.05). The incidence of nausea was also significantly lower in the ramosetron group at 24 h than in the other groups (P < 0.05). Patients in the ramosetron group were more satisfied at 2 h (8.11 ± 0.98) and 24 h (8.50 ± 0.67) after surgery than those in the other groups (P < 0.05). With regard to subgroups S and M in the placebo, ondansetron and ramosetron groups, there were no significant differences in either the incidence of nausea or patient satisfaction.Ramosetron has superior antiemetic activity to ondansetron in adult strabismus surgery patients. The number of EOMs involved in strabismus surgery was not related to the incidence of PONV.Clinical Research Information Service (CRiS) Identifier: KCT0000688 . Date of registration: 27 February 2013.

Dataset Information

Association between serotonin transport polymorphisms and postdischarge nausea and vomiting in women following breast cancer surgery.

Publications

Association between serotonin transport polymorphisms and postdischarge nausea and vomiting in women following breast cancer surgery.

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