Ontology highlight
ABSTRACT:
SUBMITTER: Assimes TL
PROVIDER: S-EPMC4023692 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Assimes Themistocles L TL Knowles Joshua W JW Priest James R JR Basu Analabha A Volcik Kelly A KA Southwick Audrey A Tabor Holly K HK Hartiala Jaana J Allayee Hooman H Grove Megan L ML Tabibiazar Raymond R Sidney Stephen S Fortmann Stephen P SP Go Alan A Hlatky Mark M Iribarren Carlos C Boerwinkle Eric E Myers Richard R Risch Neil N Quertermous Thomas T
Human genetics 20080328 4
Recent human genetic studies suggest that allelic variants of leukotriene pathway genes influence the risk of clinical and subclinical atherosclerosis. We sequenced the promoter, exonic, and splice site regions of ALOX5 and ALOX5AP and then genotyped 7 SNPs in ALOX5 and 6 SNPs in ALOX5AP in 1,552 cases with clinically significant coronary artery disease (CAD) and 1,583 controls from Kaiser Permanente including a subset of participants of the coronary artery risk development in young adults study ...[more]