Transgenic mice convert carbohydrates to essential fatty acids.
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ABSTRACT:
SUBMITTER: Pai VJ
PROVIDER: S-EPMC4023978 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Transgenic mice convert carbohydrates to essential fatty acids.
Pai Victor J VJ Wang Bin B Li Xiangyong X Wu Lin L Kang Jing X JX
PloS one 20140516 5
Transgenic mice (named "Omega mice") were engineered to carry both optimized fat-1 and fat-2 genes from the roundworm Caenorhabditis elegans and are capable of producing essential omega-6 and omega-3 fatty acids from saturated fats or carbohydrates. When maintained on a high-saturated fat diet lacking essential fatty acids or a high-carbohydrate, no-fat diet, the Omega mice exhibit high tissue levels of both omega-6 and omega-3 fatty acids, with a ratio of ∼1∶1. This study thus presents an innov ...[more]
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