Reduced genome size of Helicobacter pylori originating from East Asia.
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ABSTRACT:
SUBMITTER: Dong QJ
PROVIDER: S-EPMC4024775 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Reduced genome size of Helicobacter pylori originating from East Asia.
Dong Quan-Jiang QJ Wang Li-Li LL Tian Zi-Bing ZB Yu Xin-Jun XJ Jia Sheng-Jiao SJ Xuan Shi-Ying SY
World journal of gastroenterology 20140501 19
Helicobacter pylori (H. pylori), a major pathogen colonizing the human stomach, shows great genetic variation. Comparative analysis of strains from different H. pylori populations revealed that the genome size of strains from East Asia decreased to 1.60 Mbp, which is significantly smaller than that from Europe or Africa. In parallel with the genome reduction, the number of protein coding genes was decreased, and the guanine-cytosine content was lowered to 38.9%. Elimination of non-essential gene ...[more]
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