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Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists.

ABSTRACT: We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango ?-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.

SUBMITTER: Deng H

PROVIDER: S-EPMC4025658 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists.

Deng Huayun H Hu Haibei H Ling Shizhang S Ferrie Ann M AM Fang Ye Y

ACS medicinal chemistry letters 20120117 2

We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango β-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism. ...[more]

PMID: 24900447

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