Ontology highlight
ABSTRACT:
SUBMITTER: Haynes NE
PROVIDER: S-EPMC4025727 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Haynes Nancy-Ellen NE Scott Nathan R NR Chen Li C LC Janson Cheryl A CA Li Jia Kui JK Lukacs Christine M CM Railkar Aruna A Tozzo Effie E Whittard Toni T Brown Nicholas F NF Cheung Adrian Wai-Hing AW
ACS medicinal chemistry letters 20120808 9
3-[4-((1S,2S,3R,5S,7S)-5-Hydroxyadamantan-2-ylcarbamoyl)benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester (4) was identified as a novel, druglike and selective quinolone pan JNK inhibitor. In this communication, some of the structure-activity relationship of the azaquinolone analogues leading to 4 is discussed. The focus is on how changes at the amide functionality affected the biochemical potency, cellular potency, metabolic properties, and solubility of this ...[more]