Ontology highlight
ABSTRACT:
SUBMITTER: Hu Y
PROVIDER: S-EPMC4025737 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Hu Yaogang Y Amin Mohamad Nassir MN Padhee Shruti S Wang Rongsheng E RE Qiao Qiao Q Bai Ge G Li Yaqong Y Mathew Archana A Cao Chuanhai C Cai Jianfeng J
ACS medicinal chemistry letters 20120712 8
We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides ...[more]