RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.
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ABSTRACT:
SUBMITTER: Kakuta H
PROVIDER: S-EPMC4025743 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.
Kakuta Hiroki H Yakushiji Nobumasa N Shinozaki Ryosuke R Ohsawa Fuminori F Yamada Shoya S Ohta Yui Y Kawata Kohei K Nakayama Mariko M Hagaya Manabu M Fujiwara Chisa C Makishima Makoto M Uno Shigeyuki S Tai Akihiro A Maehara Ami A Nakayama Masaru M Oohashi Toshitaka T Yasui Hiroyuki H Yoshikawa Yutaka Y
ACS medicinal chemistry letters 20120409 5
Treating insulin resistance and type 2 diabetes in rodents, currently known retinoid X receptor (RXR) agonists induce significant adverse effects. Here we introduce a novel RXR partial agonist CBt-PMN (11b), which shows a potent glucose-lowering effect and improvements of insulin secretion and glucose tolerance without the serious adverse effects caused by RXR full agonists. We suggest that RXR partial agonists may be a new class of antitype 2 diabetes drug candidates. ...[more]
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