Ontology highlight
ABSTRACT:
SUBMITTER: Shilabin AG
PROVIDER: S-EPMC4025767 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Shilabin Abbas G AG Dzhekieva Liudmila L Misra Pushpa P Jayaram B B Pratt R F RF
ACS medicinal chemistry letters 20120604 7
Penicillin-binding proteins (PBPs) are important bacterial enzymes that carry out the final steps of bacterial cell wall assembly. Their DD-transpeptidase activity accomplishes the essential peptide cross-linking step of the cell wall. To date, all attempts to discover effective inhibitors of PBPs, apart from β-lactams, have not led to new antibiotics. Therefore, the need for new classes of efficient inhibitors of these enzymes remains. Guided by a computational fragment-based docking procedure, ...[more]