Ontology highlight
ABSTRACT:
SUBMITTER: Colbert LE
PROVIDER: S-EPMC4025946 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Colbert Lauren E LE Petrova Aleksandra V AV Fisher Sarah B SB Pantazides Brooke G BG Madden Matthew Z MZ Hardy Claire W CW Warren Matthew D MD Pan Yunfeng Y Nagaraju Ganji P GP Liu Elaine A EA Saka Burcu B Hall William A WA Shelton Joseph W JW Gandhi Khanjan K Pauly Rini R Kowalski Jeanne J Kooby David A DA El-Rayes Bassel F BF Staley Charles A CA Adsay N Volkan NV Curran Walter J WJ Landry Jerome C JC Maithel Shishir K SK Yu David S DS
Cancer research 20140313 10
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor outcomes with current therapies. Gemcitabine is the primary adjuvant drug used clinically, but its effectiveness is limited. In this study, our objective was to use a rationale-driven approach to identify novel biomarkers for outcome in patients with early-stage resected PDAC treated with adjuvant gemcitabine. Using a synthetic lethal screen in human PDAC cells, we identified 93 genes, including 55 genes linked to DNA dam ...[more]