Ontology highlight
ABSTRACT:
SUBMITTER: Kachadourian R
PROVIDER: S-EPMC4026013 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Kachadourian Remy R Day Brian J BJ Pugazhenti Subbiah S Franklin Christopher C CC Genoux-Bastide Estelle E Mahaffey Gregory G Gauthier Charlotte C Di Pietro Attilio A Boumendjel Ahcène A
Journal of medicinal chemistry 20120130 3
Chalcones continue to attract considerable interest due to their anti-inflammatory and antiangiogenic properties. We recently reported the ability of 2',5'-dihydroxychalcone (2',5'-DHC) to induce both breast cancer resistance protein-mediated export of glutathione (GSH) and c-Jun N-terminal kinase-mediated increased intracellular GSH levels. Herein, we report a structure-activity relationship study of a series of 30 synthetic chalcone derivatives with hydroxyl, methoxyl, and halogen (F and Cl) s ...[more]