Dataset Information

Radio(chemo)therapy in Elderly Patients with Esophageal Cancer: A Feasible Treatment with an Outcome Consistent with Younger Patients.

ABSTRACT:

Background

Although the prevalence of esophageal cancer increases in elderly patients, its clinical history and outcome after treatment remain poorly described.

Methods

Between January 2001 and December 2011, 58 patients (pts) older than 75?years received 3D-conformal radiotherapy (mean dose 51?Gy) in two French cancer centers. 47/58 (82%) patients received concomitant chemotherapy (with CDDP and/or FU regimens) and 8 patients underwent surgery after primary radiochemotherapy (RCT).

Results

Median age was 77.9?years and the performance status (PS) was 0 or 1 in 89%. Tumors were mainly adenocarcinoma of lower esophagus or gastroesophageal junction (n?=?51, 89%), T3T4 (n?=?54, 95%), and N1 (n?=?44, 77%). The mean follow-up was 21.9?months. In the overall population, the median progression-free survival was 9.6?months and median overall survival (OS) was 14.5?months. Using univariate analysis, OS was significantly associated with age (p?=?0.048), PS (p?ConclusionRadiochemotherapy in elderly patients is a feasible treatment and its outcome is close to younger patient's outcome published in the literature. Surgical resection, after comprehensive geriatric assessment, should be recommended as the standard treatment for adenocarcinoma of lower esophagus or gastroesophageal junction in elderly patients with good PS and low co-morbidity profile, as it is in younger patients.

SUBMITTER: Rochigneux P

PROVIDER: S-EPMC4026749 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Radio(chemo)therapy in Elderly Patients with Esophageal Cancer: A Feasible Treatment with an Outcome Consistent with Younger Patients.

Rochigneux Philippe P Resbeut Michel M Rousseau Frédérique F Bories Erwan E Raoul Jean-Luc JL Poizat Flora F Moureau-Zabotto Laurence L

Frontiers in oncology 20140512

<h4>Background</h4>Although the prevalence of esophageal cancer increases in elderly patients, its clinical history and outcome after treatment remain poorly described.<h4>Methods</h4>Between January 2001 and December 2011, 58 patients (pts) older than 75 years received 3D-conformal radiotherapy (mean dose 51 Gy) in two French cancer centers. 47/58 (82%) patients received concomitant chemotherapy (with CDDP and/or FU regimens) and 8 patients underwent surgery after primary radiochemotherapy (RCT ...[more]

PMID: 24860783

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Project description:BACKGROUND:Radiotherapy treatment of head and neck cancer affects local arteries and increases the risk of stroke. This study aimed at a closer characterization of this damage and its development in time with a longitudinal study set up. METHODS:Male patients treated between 2011 and 2016 for hypopharyngeal carcinoma were identified from the in-house clinical data base. They were included into the study if besides the planning CT at least one additional CT image was available from follow-up (13 patients) or at least two MRI scans (16 patients of which 2 were already included). All patients received radiotherapy, and chemotherapy was administered to 16 patients. The time from the beginning of radiotherapy to the last available image ranged from 2?months to 4.5?years. For six segments of the carotid arteries, the number and volume of atherosclerotic plaques were determined from the CT scans, and the intima media thickness from the MRI scans. Information on comorbid cardiovascular disease, hypertension and diabetes mellitus was retrieved from medical records. RESULTS:Total plaque volume rose from 0.25?cm3 before to 0.33?cm3 after therapy but this was not significant (p?=?0.26). The mean number of plaques increased from 5.7 to 8.1 (p?=?0.002), and the intima media thickened from 1.17?mm to 1.35?mm (p?=?0.002). However, the mean intima media thickness practically did not change in patients with comorbid diabetes mellitus (p-value for homogeneity: 0.03). For patients without diabetes mellitus, dynamics of both plaque number and intima media thickness, was consistent with an increase until about one year after therapy and no further progression thereafter. CONCLUSION:Our study confirmed the thickening of artery walls and the increase in the number of plaques. Results imply that definitive radiation damage to the artery walls can be determined not earlier than about one year after radiotherapy and there is no substantial deterioration thereafter. Reasons for the absence of an observable intima media thickening in patients with diabetes are unclear.

Dataset Information

Radio(chemo)therapy in Elderly Patients with Esophageal Cancer: A Feasible Treatment with an Outcome Consistent with Younger Patients.

Background

Methods

Results

Publications

Radio(chemo)therapy in Elderly Patients with Esophageal Cancer: A Feasible Treatment with an Outcome Consistent with Younger Patients.

Similar Datasets

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