Ontology highlight
ABSTRACT:
SUBMITTER: Capelluto DG
PROVIDER: S-EPMC4026774 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Capelluto Daniel G S DG Zhao Xiaolin X Lucas Andrew A Lemkul Justin A JA Xiao Shuyan S Fu Xiangping X Sun Furong F Bevan David R DR Finkielstein Carla V CV
Biophysical journal 20140301 5
The Wnt-dependent, β-catenin-independent pathway modulates cell movement and behavior. A downstream regulator of this signaling pathway is Dishevelled (Dvl), which, among other multiple interactions, binds to the Frizzled receptor and the plasma membrane via phosphatidic acid (PA) in a mechanism proposed to be pH-dependent. While the Dvl DEP domain is central to the β-catenin-independent Wnt signaling function, the mechanism underlying its physical interaction with the membrane remains elusive. ...[more]