Ontology highlight
ABSTRACT:
SUBMITTER: Thouta S
PROVIDER: S-EPMC4026777 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Thouta Samrat S Sokolov Stanislav S Abe Yuki Y Clark Sheldon J SJ Cheng Yen M YM Claydon Tom W TW
Biophysical journal 20140301 5
In Shaker-like channels, the activation gate is formed at the bundle crossing by the convergence of the inner S6 helices near a conserved proline-valine-proline motif, which introduces a kink that allows for electromechanical coupling with voltage sensor motions via the S4-S5 linker. Human ether-a-go-go-related gene (hERG) channels lack the proline-valine-proline motif and the location of the intracellular pore gate and how it is coupled to S4 movement is less clear. Here, we show that proline s ...[more]