A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases.
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ABSTRACT:
SUBMITTER: Staderini M
PROVIDER: S-EPMC4027132 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases.
Staderini Matteo M Aulić Suzana S Bartolini Manuela M Tran Hoang Ngoc Ai HN González-Ruiz Víctor V Pérez Daniel I DI Cabezas Nieves N Martínez Ana A Martín M Antonia MA Andrisano Vincenza V Legname Giuseppe G Menéndez J Carlos JC Bolognesi Maria Laura ML
ACS medicinal chemistry letters 20121228 2
(E)-6-Methyl-4'-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both Aβ and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits Aβ self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furth ...[more]
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