New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.
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ABSTRACT:
SUBMITTER: Friggeri L
PROVIDER: S-EPMC4027138 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.
Friggeri Laura L Scipione Luigi L Costi Roberta R Kaiser Marcel M Moraca Francesca F Zamperini Claudio C Botta Bruno B Di Santo Roberto R De Vita Daniela D Brun Reto R Tortorella Silvano S
ACS medicinal chemistry letters 20130507 6
The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells. ...[more]
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