Ontology highlight
ABSTRACT:
SUBMITTER: Falanga A
PROVIDER: S-EPMC4027185 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Nucleic acids research 20140401 9
Exon splicing enhancers (ESEs) overlap with amino acid coding sequences implying a dual evolutionary selective pressure. In this study, we map ESEs in the placental alkaline phosphatase gene (ALPP), absent in the corresponding exon of the ancestral tissue-non-specific alkaline phosphatase gene (ALPL). The ESEs are associated with amino acid differences between the transcripts in an area otherwise conserved. We switched out the ALPP ESEs sequences with the sequence from the related ALPL, introduc ...[more]