Ontology highlight
ABSTRACT:
SUBMITTER: Andayi WA
PROVIDER: S-EPMC4027233 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20130520 7
A series of noncytotoxic 4-aminoquinoline-3-hydroxypyridin-4-one hybrids were synthesized on the basis of a synergistic in vitro combination of a precursor N-alkyl-3-hydroxypyridin-4-one with chloroquine (CQ) and tested in vitro against CQ resistant (K1 and W2) and sensitive (3D7) strains of Plasmodium falciparum. In vitro antiplasmodial activity of the precursors was negated by blocking the chelator moiety via complexation with gallium(III) or benzyl protection. None of the precursors inhibited ...[more]