Ontology highlight
ABSTRACT:
SUBMITTER: Giordanetto F
PROVIDER: S-EPMC4027235 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20131016 12
Agonists of vasoactive intestinal peptide receptor 2 (VPAC2) stimulate glucose-dependent insulin secretion, making them attractive candidates for the treatment of hyperglycaemia and type-II diabetes. Vasoactive intestinal peptide (VIP) is an endogenous peptide hormone that potently agonizes VPAC2. However, VIP has a short serum half-life and poor pharmacokinetics in vivo and is susceptible to proteolytic degradation, making its development as a therapeutic agent challenging. Here, we investigate ...[more]