Ontology highlight
ABSTRACT:
SUBMITTER: Rempel V
PROVIDER: S-EPMC4027495 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Rempel Viktor V Fuchs Alexander A Hinz Sonja S Karcz Tadeusz T Lehr Matthias M Koetter Uwe U Müller Christa E CE
ACS medicinal chemistry letters 20121114 1
The bark of Magnolia officinalis is used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. We found that the extract and its main bioactive constituents, magnolol and honokiol, can activate cannabinoid (CB) receptors. In cAMP accumulation studies, magnolol behaved as a partial agonist (EC50 = 3.28 μM) with selectivity for the CB2 subtype, while honokiol was less potent showing full agonistic activity at CB1 and antagonistic properties at CB2. ...[more]